• What is Proteoglycan

①Sulfated polysaccharides called glycosaminoglycans such as chondroitin sulfate, dermatan sulfate, heparin sulfare, heparin, and keratin sulfate are covalently bonded to a protein (referred to as core protein). In a broad sense, it is a kind of glycoprotein.

②Proteoglycan exists on the cell surface as well as in the extracellular matrix of animals. Here, they form complexes to hyaluronic acid, and to fibrous matrix protein, such as collagen. Proteoglycans function in attracting and retaining moisture in the cartilage.

  • What is extracellular matrix?

It is the "filler" substance existing between cells. Rather than being fed directly into the cell, nutrients, oxygen, and water that was carried through the blood vessels, they are temporarily stored in the extracellular matrix. Then they are supplied to each cell as required. 

Furthermore, waste discharged from the cell also goes to the extracellular matrix temporarily, after which they are returned to the vein through the capillaries.

Thus, in order for cells to work, extracellular matrix plays an important supporting role. And within the core of this extracellular matrix is the proteoglycan.


  • What is EGF effect of proteoglycan?

EGF or Epidermal Growth Factor is a protein which was first discovered by Nobel Prize American Scientist, Stanley Cohen. EGF belongs to a superfamily which holds the key for stimulating cell regeneration.  Its function is comprehensive in protecting the skin structure and condition.

Even in proteoglycan found in the salmon nasal cavity, there is a region for binding hyaluronic acid at one end of the core protein, on the other end of the terminal is a region that is structurally similar to epidermal growth factor (EGF).


  • What are the physiological functions of proteoglycan? How about its applications?

① Food and Medicine: anti-inflammatory effect→ anti-allergic action → treatment of ulcerative colitis

② Cosmetic: anti-Aging Effect: cell growth stimulating effect→ youthful skin regeneration effect

③ Pharmaceutical material: Cartilage regeneration-promoting action → treatment of senile arthritis

(medical material)                                           

④ Food and Medicine: bone metabolism disorder improvement effect→ osteoporosis, healing effect

⑤ Cosmetic Food: Moisturizing effect → Application to cosmetic food 


  • Who is the target market for proteoglycan?

Cosmetics and health food manufacturer


  • How can I order proteoglycan and other products sample?

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  • How can I order proteoglycan and other products?

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Proteoglycan Sugar Chain Structure

Proteoglycan plays an important in protecting the skin structure and condition

Proteoglycan promotes cartilage healing and regeneration

Application as Anti-Aging Cosmetics

Application for health food and supplements