Strong Points and Features

(1)Characteristics as a health food ingredient  <ability to have cushioning effect for joint elasticity>

◆The extracellular matrix is necessary as a resting and working place in the cells that form the body.

 It is wrapped around the cell habitats, and within it are the proteoglycans which play a very important role in the skin and joint cartilage. Proteoglycans become insufficient as we age, thus supplementing it from outside source can protect us from joint pain and weakening of the skin. 

◆ Nondigestible

Proteoglycan is not digestible; it is not easily decomposed by the stomach acid. For this reason, it passes through the stomach maintaining its high molecular state. However due to the decomposing enzymes in the small intestine, it is broken down up to a certain size. This decomposition product becomes the immunizing antigen M cells (micro-fold cells) as it passes through and which has been thought to bind with the immune cells. Eventually, it is considered to be enzymatically decomposed in the liver. Those that were not decomposed will be excreted in the urine.

◆Relationship of proteoglycan with the cartilage

In damaged or injured cartilage, the enzymes that tear down the cartilage are out of control; collagen network melts; and the proteoglycans are thrown off. In addition, cartilage with reduced proteoglycan is weak to shock, can break easily, and also loses its water content. Cartilage can stretch and contract due to the presence of proteoglycan. As long as there are lots of proteoglycans cartilage is healthy and vibrant.


(2) Feature as a Cosmetic Ingredient  <forms a dermal stereoscopic structure which gives elasticity to the skin>

◆ Moisture retention property exceeds Hyaluronic acid by 30%

Proteoglycan’s moisture retention property is high; also it has a good affinity with Hyaluronic acid. Furthermore, another attraction is the epidermal growth factor or (EGF) like component of the C-terminus present in the core protein which cannot be found in other materials, it is a very appealing as cosmetic ingredient. It is comparable to using EGF alone, using it as a cosmetic ingredient is extremely appealing. As compared to using EGF alone, it is better to use proteoglycan, as it has been confirmed to provide better cell proliferation.

 Taken orally, monitor test results has been published on its power to improve moisture-retaining capacity of the skin and sebum content. In addition, whether taken orally or applied topically, improvement in blood circulation has been confirmed.

 *EGF - The so called EGF (Epidermal Growth Factor) is the “epithelial cell proliferation (growth) factor” which plays an important role in the coordination of cell growth and proliferation. It has been confirmed that as we age, EGF quantity decreases; for this reason metabolism, as well as regenerative ability of the cells declined. As EGF type domain is present in proteoglycans, proteoglycans from salmon nasal cartilage has the EGF-type effect as confirmed by the Hirosaki University.

Cushioning Effect for Joint Elasticity

Lots of Proteoglycan means Cartilage is Healthy and Vibrant

Forms a Dermal Stereoscopic Structure which gives Elasticity to the Skin 

Moisture Retention Capacity Exceeds that of Hyaluronic Acid by 30%