Proteoglycan is a kind of “glycoprotein” consisting of sugar chains bonded to a core protein; it is one of the components that configure the human cartilage and skin.

Next to collagen and hyaluronic acid, it is the supplement recommended for beautiful skin, and a functional food for treatment of hip and knee joint pain.

Hyaluronic acid and proteoglycans are the components responsible for the water retention capability of the skin, as these components decreases with age, signs of skin aging becomes apparent.

These proteoglycans, found in the dermis layer deep into the skin, are the components responsible for water retention, as well as cushioning function for the skin and joints.

Due to its feather-like structure, proteoglycan has water retention and cushioning property 30% more than that of hyaluronic acid.

Furthermore, unlike any other materials, it has a property similar to EGF (Epidermal Growth Factor) which promotes skin cell regeneration. As, compared with using EGF alone, proteoglycan is proven to be more effective in promoting cell proliferation, making it a very attractive beauty substance.

In addition, proteoglycans are one of the components which make up the cartilage which is called the cartilage matrix. It suppresses inflammation, reduces pain, and concurrently promotes cartilage regeneration.

Recommended dosage       Proteoglycan 5-15mg/day

As a health food ingredient, proteoglycan has the ability to provide a cushioning effect for the joints, as well as give elasticity to the skin.


The extracellular matrix is necessary as a resting and working place in the cells that form the body. It is wrapped around the cell habitats; within this area are the proteoglycans which play a very important role in the skin and joint cartilage.

Proteoglycans become insufficient as we age, thus supplementing it from outside source can protect us from joint pain and weakening of the skin.


Proteoglycan is nondigestible; it is not easily decomposed by the stomach acid. For this reason, it passes through the stomach maintaining its high molecular state.

Due to the decomposing enzymes in the small intestine, it is broken down up to a certain size. This decomposition product becomes the immunizing antigen M cells (micro-fold cells) as it passes through and which has been thought to bind with the immune cells positively affecting immune functions.

Eventually, it is considered to be enzymatically decomposed in the liver. Those that were not decomposed will be excreted in the urine.



In damaged or injured cartilage, the enzymes that tear down the cartilage are out of control; collagen network melts; and the proteoglycans are thrown off.

In addition, cartilage with reduced proteoglycan is weak to shock, can break easily, and also loses its water content. Cartilage can stretch and contract due to the presence of proteoglycan.

As long as there are lots of proteoglycans cartilage is healthy and vibrant.